The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of
these roles is T cell shape development and movement, including formation of the …

▪ Abstract T cells constantly sample their environment using receptors (TCR) that possess
both a germline-encoded low affinity for major histocompatibility complex (MHC) molecules …

T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction
by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was …

How T cells respond with extraordinary sensitivity to minute amounts of agonist peptide and
major histocompatibility complex (pMHC) molecules on the surface of antigen-presenting …

We present proximity sequencing (Prox-seq) for simultaneous measurement of proteins,
protein complexes and mRNAs in thousands of single cells. Prox-seq combines proximity …

We present experiments in which single proteins were imaged and tracked within
mammalian cells. Single proteins of R-phycoerythrin (RPE) were imaged by epifluorescence …

Adaptive immunity depends on specific recognition by a T-cell receptor (TCR) of an
antigenic peptide bound to a major histocompatibility complex (pMHC) molecule on an …

MHC molecules are not randomly distributed on the plasma membrane but instead are
present in discrete nanoclusters. The mechanisms that control formation of MHC I …

Complexes of peptide and major histocompatibility complex (MHC) class II are expressed on
the surface of antigen-presenting cells but their molecular organization is unknown. Here we …

Single-particle tracking (SPT) was used to determine the mobility characteristics of MHC
(major histocompatibility complex) class I molecules at the surface of HeLa cells at 22° C …