One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

More than a decade after a Nobel Prize was awarded for the discovery of the ubiquitin–
proteasome system and clinical approval of proteasome and ubiquitin E3 ligase inhibitors …

The incidence of primary cutaneous melanoma continues to increase each year. Melanoma
accounts for the majority of skin cancer–related deaths, but treatment is usually curative …

Cancer is a global issue majorly affecting developing countries. According to a survey, 63%
of deaths due to cancer are reported from developing countries. There are different …

We performed genomic, epigenomic, transcriptomic, and proteomic characterizations of
uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations …

Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, we discovered
frequent inactivating mutations in multiple chromatin-remodeling genes (including BAP1 …

Background Cholangiocarcinoma (CCA) is clinically heterogeneous; intra and extrahepatic
CCA have diverse clinical presentations. Next generation sequencing (NGS) technology …

Abstract Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer
deaths in the United States alone. The public health burden associated with these numbers …

The incidence of primary cutaneous melanoma has been increasing dramatically for several
decades. Melanoma accounts for the majority of skin cancer–related deaths, but treatment is …

Introduction: Heritage is the most important risk factor for breast cancer. About 15–20% of
breast cancer is familial, referring to affected women who have one or more first-or second …