Abstract Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through
transcriptional regulation of immunologically relevant genes. This article reviews the current …

Investigation into the mechanism of cytokine signaling led to the discovery of the JAK/STAT
pathway. Following the binding of cytokines to their cognate receptor, signal transducers …

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the
IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into …

IFN-γ is one of the key cytokines in defining Th1 immune responses. In this study, an IFN-γ
homologue has been identified in rainbow trout Oncorhynchus mykiss, and its biological …

Type I interferons (IFNs) elicit antiviral, antiproliferative and immunmodulatory responses by
binding to a shared cell surface receptor comprising the transmembrane proteins ifnar1 and …

Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic
levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor …

Proteins actively transported into the nucleus via the classical nuclear import pathway
contain nuclear localization signals (NLSs), which are recognized by the family of importin α …

Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation
(“activation”) of Stat proteins at the cell membrane. This rapidly leads to their accumulation in …

Signal transducer and activator of transcription (STAT) proteins are cytoplasmic transcription
factors that translocate to the nucleus and regulate gene expression upon activation of …

Signal transducers and activators of transcription (STATs) are latent cytoplasmic
transcription factors, which mediate interferon (IFN), interleukin, and some growth factor and …