Circulating alpha 1-antitrypsin is synthesized primarily in the liver and secreted into the
bloodstream, where it serves as the major protease inhibitor. The PiZ variant of alpha 1 …

To localize the cellular sources of the collagens excessively deposited in the liver in the
course of secondary biliary fibrosis, we have analyzed by in situ hybridization the distribution …

The expression of α2 (I), α1 (III) and α1 (IV) procollagen mRNA was analyzed in normal and
CCl4‐induced fibrotic rat liver by in situ hybridization using RNA probes. In normal liver …

Skin biopsies from seven patients with localized scleroderma (morphea) and from two
healthy individuals were studied by in situ hybridization to localize the cells responsible for …

The authors have determined the cell types producing alpha 1 (I), alpha 2 (I), alpha 1 (III),
and alpha 1 (IV) procollagen gene transcripts in adult human liver by in situ hybridization …

The cellular origin of hepatic collagen is under active investigation. Several recent studies
using cells in primary culture suggest that hepatocytes are the source of much of the …

It is a moot question as to whether schistosomiasis is an" unusual infective agent" of liver
disease. On the one hand, there is Egypt, where 50% of the population is infected with …

We have used the silica-induced model of pulmonary injury in the rat to study the pattern of
collagen expression in granulomatous lung inflammation. A single intratracheal instillation of …

To further our studies on collagen gene expression, we have evaluated the molecular basis
for the finding that steroids decrease collagen synthesis in cultured hepatocytes. We studied …

The arrival of eggs in the liver during Schistosoma mansoni infection initiates a protective
granulomatous response; however, as the infection progresses, this response results in …