Interaction of the T cell receptor (TCR) with an MHC-antigenic peptide complex results in
changes at the molecular and cellular levels in T cells. The outside environmental cues are …

NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

We report the updated classification of inborn errors of immunity, compiled by the
International Union of Immunological Societies Expert Committee. This report documents the …

Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Adoptive T cell therapy has achieved dramatic success in a clinic, and the Food and Drug
Administration approved two chimeric antigen receptor-engineered T cell (CAR-T) therapies …

Abstract Background N6‐methyladenosine (m6A) methylation, a well‐known modification
with new epigenetic functions, has been reported to participate in gastric cancer (GC) …

T cells possess an array of functional capabilities important for host defense against
pathogens and tumors. T cell effector functions require the T cell antigen receptor (TCR) …

At sites of inflammation, ligation of leukocyte integrins is critical for the activation of cellular
effector functions required for host defense. However, the signaling pathways linking integrin …

Signal transduction events leading to the survival, differentiation, or apoptosis of cells of the
innate or adaptive immune system must be properly coordinated to ensure the normal …