Role of neuroinflammation in neurodegeneration development
Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that …
Alpha synuclein: neurodegeneration and inflammation
G Forloni - International journal of molecular sciences, 2023 - mdpi.com
Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …
pathogenesis of Parkinson's disease and related disorders, synucleinopathies, but also in …
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …
over 176,000 individuals with Parkinson's disease (PD) and Alzheimer's disease (AD) …
Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
Phosphorylation of α-synuclein at the serine-129 site (α-syn Ser129P) is an established
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
pathologic hallmark of synucleinopathies and a therapeutic target. In physiologic states, only …
One-step nanoscale expansion microscopy reveals individual protein shapes
AH Shaib, AA Chouaib, R Chowdhury, J Altendorf… - Nature …, 2024 - nature.com
The attainable resolution of fluorescence microscopy has reached the subnanometer range,
but this technique still fails to image the morphology of single proteins or small molecular …
but this technique still fails to image the morphology of single proteins or small molecular …
α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson's disease
Background Pathological accumulation of aggregated α-synuclein (aSYN) is a common
feature of Parkinson's disease (PD). However, the mechanisms by which intracellular aSYN …
feature of Parkinson's disease (PD). However, the mechanisms by which intracellular aSYN …
Are therapies that target α-synuclein effective at halting Parkinson's disease progression? A systematic review
AT Rodger, M ALNasser, WG Carter - International Journal of Molecular …, 2023 - mdpi.com
There are currently no pharmacological treatments available that completely halt or reverse
the progression of Parkinson's Disease (PD). Hence, there is an unmet need for …
the progression of Parkinson's Disease (PD). Hence, there is an unmet need for …
Pathogenesis of α-Synuclein in Parkinson's Disease: From a Neuron-Glia Crosstalk Perspective
S Yi, L Wang, H Wang, MS Ho, S Zhang - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder. The classical
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
behavioral defects of PD patients involve motor symptoms such as bradykinesia, tremor, and …
Alpha‐synuclein‐associated changes in PINK1‐PRKN‐mediated mitophagy are disease context dependent
Alpha‐synuclein (αsyn) aggregates are pathological features of several neurodegenerative
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …