Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer
During disease progression from primary towards metastatic prostate cancer (PCa), and in
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …
Emerging strategies for treating metastasis
The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …
cancer, yet few successful therapeutic strategies have emerged to specifically target …
Notch signaling and the skeleton
S Zanotti, E Canalis - Endocrine reviews, 2016 - academic.oup.com
Notch 1 to 4 receptors are important determinants of cell fate and function, and Notch
signaling plays an important role in skeletal development and bone remodeling. After direct …
signaling plays an important role in skeletal development and bone remodeling. After direct …
Targeting the mitogen-activated protein kinase cascade to treat cancer
JS Sebolt-Leopold, R Herrera - Nature reviews cancer, 2004 - nature.com
The RAS–mitogen activated protein kinase (MAPK) signalling pathway has long been
viewed as an attractive pathway for anticancer therapies, based on its central role in …
viewed as an attractive pathway for anticancer therapies, based on its central role in …
Metastasis: recent discoveries and novel treatment strategies
SA Eccles, DR Welch - The Lancet, 2007 - thelancet.com
Most cancer deaths are due to the development of metastases, hence the most important
improvements in morbidity and mortality will result from prevention (or elimination) of such …
improvements in morbidity and mortality will result from prevention (or elimination) of such …
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
Nearly every extracellular ligand that has been found to play a role in regulating bone
biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be …
biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be …
Critical role of the extracellular signal–regulated kinase–MAPK pathway in osteoblast differentiation and skeletal development
C Ge, G Xiao, DI Jiang, RT Franceschi - The Journal of cell biology, 2007 - rupress.org
The extracellular signal–regulated kinase (ERK)–mitogen-activated protein kinase (MAPK)
pathway provides a major link between the cell surface and nucleus to control proliferation …
pathway provides a major link between the cell surface and nucleus to control proliferation …
Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer
A Bellahcène, V Castronovo, KUE Ogbureke… - Nature Reviews …, 2008 - nature.com
Numerous components and pathways are involved in the complex interplay between cancer
cells and their environment. The family of glycophosphoproteins comprising osteopontin …
cells and their environment. The family of glycophosphoproteins comprising osteopontin …
The biology of bone metastasis
Bone metastasis, or the development of secondary tumors within the bone of cancer
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …
Tumour-derived alkaline phosphatase regulates tumour growth, epithelial plasticity and disease-free survival in metastatic prostate cancer
SR Rao, AE Snaith, D Marino, X Cheng, ST Lwin… - British journal of …, 2017 - nature.com
Background: Recent evidence suggests that bone-related parameters are the main
prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated …
prognostic factors for overall survival in advanced prostate cancer (PCa), with elevated …