Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Background Migraine is a common and often debilitating neurological disease. It can be
divided into episodic and chronic subforms based on the number of monthly headache days …

Medication-overuse headache (MOH) is defined by the International Classification of
Headache Disorders as a headache in patients with a pre-existing primary headache …

Objective: To determine calcitonin gene-related peptide (CGRP) levels outside migraine
attacks in peripheral blood as a potential biomarker for chronic migraine (CM). Methods …

Objectives: This is the second of a pair of studies designed to evaluate the efficacy and
safety of onabotulinumtoxinA (BOTOX®) for prophylaxis of headaches in adults with chronic …

Objectives: This is the first of a pair of studies designed to assess efficacy, safety and
tolerability of onabotulinumtoxinA (BOTOX®) as headache prophylaxis in adults with chronic …

(Headache 2010; 50: 921‐936) Objective.—To assess the efficacy, safety, and tolerability of
onabotulinumtoxinA (BOTOX®) as headache prophylaxis in adults with chronic migraine …

Migraine is a common disabling primary headache disorder that affects an estimated 36
million A mericans. Migraine headaches often occur over many years or over an individual's …

Background: Migraine imposes significant burden on patients, their families and health care
systems. In this study, we compared episodic to chronic migraine sufferers to determine if …

Objective: To evaluate the feasibility, safety, and tolerability of noninvasive vagus nerve
stimulation (nVNS) for the prevention of chronic migraine (CM) attacks. Methods: In this first …