DNA methylation cancer biomarkers: translation to the clinic
Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …
These changes are characterized by a globally hypomethylated genome with focal …
Rising incidence of early‐onset colorectal cancer in A ustralia over two decades: Report and review
The average age at diagnosis for colorectal cancer (CRC) in A ustralia is 69, and the age‐
specific incidence rises rapidly after age 50 years. The incidence has stabilized or is …
specific incidence rises rapidly after age 50 years. The incidence has stabilized or is …
Novel DNA methylation biomarkers show high sensitivity and specificity for blood-based detection of colorectal cancer—a clinical biomarker discovery and validation …
SØ Jensen, N Øgaard, MBW Ørntoft, MH Rasmussen… - Clinical …, 2019 - Springer
Background Early detection plays an essential role to reduce colorectal cancer (CRC)
mortality. While current screening methods suffer from poor compliance, liquid biopsy-based …
mortality. While current screening methods suffer from poor compliance, liquid biopsy-based …
Circulating extracellular vesicle microRNA as diagnostic biomarkers in early colorectal cancer—A review
BJ Desmond, ER Dennett, KM Danielson - Cancers, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies in the developed world,
with global deaths expected to double in the next decade. Disease stage at diagnosis is the …
with global deaths expected to double in the next decade. Disease stage at diagnosis is the …
Evaluation of an assay for methylated BCAT1 and IKZF1 in plasma for detection of colorectal neoplasia
SK Pedersen, EL Symonds, RT Baker, DH Murray… - BMC cancer, 2015 - Springer
Background Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency
in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA …
in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA …
Cell-free DNA as a diagnostic blood-based biomarker for colorectal cancer: a systematic review
Abstract Background Circulating tumour DNA (ctDNA) has emerged as an excellent
candidate for the future of liquid biopsies for many cancers. There has been growing interest …
candidate for the future of liquid biopsies for many cancers. There has been growing interest …
A Blood Test for MethylatedBCAT1andIKZF1vs. a Fecal Immunochemical Test for Detection of Colorectal Neoplasia
EL Symonds, SK Pedersen, RT Baker… - Clinical and …, 2016 - journals.lww.com
OBJECTIVES: To compare the performance of a new blood test for colorectal cancer (CRC)
to an established fecal immunochemical test (FIT) in a study population with the full range of …
to an established fecal immunochemical test (FIT) in a study population with the full range of …
Blood-based protein biomarker panel for the detection of colorectal cancer
Background The majority of colorectal cancer (CRC) cases are preventable by early
detection and removal of precancerous polyps. Even though CRC is the second most …
detection and removal of precancerous polyps. Even though CRC is the second most …
Exosomal microRNA biomarkers: emerging frontiers in colorectal and other human cancers
Diagnostic strategies, particularly non-invasive blood-based screening approaches, are
gaining increased attention for the early detection and attenuation of mortality associated …
gaining increased attention for the early detection and attenuation of mortality associated …
[HTML][HTML] Colorectal cancer in the young, many questions, few answers
At a time where the incidence of colorectal cancer, a disease predominantly of developed
nations, is showing a decline in those 50 years of age and older, data from the West is …
nations, is showing a decline in those 50 years of age and older, data from the West is …