Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Interferons are innate and adaptive cytokines involved in many biological responses, in
particular, viral infections. With the final response the result of the balance of the different …

Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while
minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …

Influenza A virus (IAV) polymerase protein PB2 has been shown to partially inhibit the host
immune response by blocking the induction of interferons (IFNs). However, the IAV PB2 …

The immune system protects the organism against infections and the damage associated
with them. The first line of defense against pathogens is the innate immune response. In the …

Re-emerging and new viral pathogens have caused significant morbidity and mortality
around the world, as evidenced by the recent monkeypox, Ebola and Zika virus outbreaks …

Most anti-influenza drugs currently used, such as oseltamivir and zanamivir, inhibit the
enzymatic activity of neuraminidase. However, neuraminidase inhibitor-resistant viruses …

Summary Type I interferon (IFN-I) signaling is central to inducing antiviral innate immunity.
However, the mechanisms for IFN-I signaling self-regulation are still largely unknown. Here …

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is
covalently attached to a target protein to influence protein stability, interaction partner and …