Non-specific low back pain

F Balagué, AF Mannion, F Pellisé, C Cedraschi - The lancet, 2012 - thelancet.com
Non-specific low back pain has become a major public health problem worldwide. The
lifetime prevalence of low back pain is reported to be as high as 84%, and the prevalence of …

Pathobiology of Modic changes

S Dudli, AJ Fields, D Samartzis, J Karppinen… - European Spine …, 2016 - Springer
Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

[HTML][HTML] Disc in flames: roles of TNF-α and IL-1β in intervertebral disc degeneration

ZI Johnson, ZR Schoepflin, H Choi… - European cells & …, 2015 - ncbi.nlm.nih.gov
The intervertebral disc is an important mechanical structure that allows range of motion of
the spinal column. Degeneration of the intervertebral disc, incited by aging, traumatic insult …

Modic changes of the lumbar spine: prevalence, risk factors, and association with disc degeneration and low back pain in a large-scale population-based cohort

FPS Mok, D Samartzis, J Karppinen, DYT Fong… - The spine journal, 2016 - Elsevier
Abstract Background Context Modic changes (MC) are bone marrow lesions on magnetic
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …

Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of …

HB Albert, JS Sorensen, BS Christensen… - European Spine …, 2013 - Springer
Purpose Modic type 1 changes/bone edema in the vertebrae are present in 6% of the
general population and 35–40% of the low back pain population. It is strongly associated …

Does nuclear tissue infected with bacteria following disc herniations lead to Modic changes in the adjacent vertebrae?

HB Albert, P Lambert, J Rollason, JS Sorensen… - European Spine …, 2013 - Springer
Purpose To investigate the prevalence of infected herniated nucleus material in lumbar disc
herniations and to determine if patients with an anaerobic infected disc are more likely to …

Modic changes—their associations with low back pain and activity limitation: a systematic literature review and meta-analysis

C Herlin, P Kjaer, A Espeland, JS Skouen… - PloS one, 2018 - journals.plos.org
Background Previous systematic reviews have reported positive associations between
Modic changes (MCs) and low back pain (LBP), but due to their narrow scope and new …

Vertebral endplate signal changes (Modic change): a systematic literature review of prevalence and association with non-specific low back pain

TS Jensen, J Karppinen, JS Sorensen… - European Spine …, 2008 - Springer
The prevalence of “vertebral endplate signal changes”(VESC) and its association with low
back pain (LBP) varies greatly between studies. This wide range in reported prevalence …

Evaluation and treatment of low back pain: a clinically focused review for primary care specialists

WM Hooten, SP Cohen - Mayo clinic proceedings, 2015 - Elsevier
Low back pain (LBP) is a leading cause of disability worldwide. In the absence of a
classification system for pain syndromes, classification of LBP on the basis of the distribution …

The American Society of Pain and Neuroscience (ASPN) evidence-based clinical guideline of interventional treatments for low back pain

D Sayed, J Grider, N Strand, JM Hagedorn… - Journal of Pain …, 2022 - Taylor & Francis
Introduction Painful lumbar spinal disorders represent a leading cause of disability in the US
and worldwide. Interventional treatments for lumbar disorders are an effective treatment for …