Epidemiology of lung cancer
Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an
estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the …
estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the …
Unravelling the biology of SCLC: implications for therapy
Small-cell lung cancer (SCLC) is an aggressive malignancy associated with a poor
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …
prognosis. First-line treatment has remained unchanged for decades, and a paucity of …
[HTML][HTML] High tumor mutation burden fails to predict immune checkpoint blockade response across all cancer types
Background High tumor mutation burden (TMB-H) has been proposed as a predictive
biomarker for response to immune checkpoint blockade (ICB), largely due to the potential for …
biomarker for response to immune checkpoint blockade (ICB), largely due to the potential for …
Health effects associated with smoking: a Burden of Proof study
X Dai, GF Gil, MB Reitsma, NS Ahmad, JA Anderson… - Nature medicine, 2022 - nature.com
As a leading behavioral risk factor for numerous health outcomes, smoking is a major
ongoing public health challenge. Although evidence on the health effects of smoking has …
ongoing public health challenge. Although evidence on the health effects of smoking has …
RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues
INTRODUCTION Cancer genome studies have contributed to the analysis and discovery of
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
somatic mutations that drive cancer growth. However, studying the genetic makeup of a …
Trends in the incidence, treatment, and survival of patients with lung cancer in the last four decades
T Lu, X Yang, Y Huang, M Zhao, M Li, K Ma… - Cancer management …, 2019 - Taylor & Francis
Purpose This study used the Surveillance, Epidemiology, and End Results (SEER) data to
investigate the changes in incidence, treatment, and survival of lung cancer from 1973 to …
investigate the changes in incidence, treatment, and survival of lung cancer from 1973 to …
Mutational signatures associated with tobacco smoking in human cancer
Tobacco smoking increases the risk of at least 17 classes of human cancer. We analyzed
somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking …
somatic mutations and DNA methylation in 5243 cancers of types for which tobacco smoking …
Pembrolizumab in patients with extensive-stage small-cell lung cancer: results from the phase Ib KEYNOTE-028 study
PA Ott, E Elez, S Hiret, DW Kim, A Morosky… - Journal of Clinical …, 2017 - ascopubs.org
Purpose The safety and efficacy of pembrolizumab, a humanized monoclonal antibody
against programmed death 1 (PD-1), were assessed in patients with programmed death …
against programmed death 1 (PD-1), were assessed in patients with programmed death …
Interaction between the microbiome and TP53 in human lung cancer
Background Lung cancer is the leading cancer diagnosis worldwide and the number one
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …
cause of cancer deaths. Exposure to cigarette smoke, the primary risk factor in lung cancer …
The comparison between adenocarcinoma and squamous cell carcinoma in lung cancer patients
BY Wang, JY Huang, HC Chen, CH Lin, SH Lin… - Journal of cancer …, 2020 - Springer
Background There are several studies comparing the difference between adenocarcinoma
(AC) and squamous cell carcinoma (SqCC) of lung cancer. However, seldom studies …
(AC) and squamous cell carcinoma (SqCC) of lung cancer. However, seldom studies …