Mass-spectrometric exploration of proteome structure and function
R Aebersold, M Mann - Nature, 2016 - nature.com
Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Protein–small molecule interactions in native mass spectrometry
JL Bennett, GTH Nguyen, WA Donald - Chemical Reviews, 2021 - ACS Publications
Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …
scientific methodologies to occasion therapeutic advances. Although established …
The power of ion mobility-mass spectrometry for structural characterization and the study of conformational dynamics
Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …
Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule
The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule
were systematically analyzed using radical scavenging assays and ELISA kits. By this …
were systematically analyzed using radical scavenging assays and ELISA kits. By this …
Structures of a complete human V-ATPase reveal mechanisms of its assembly
Vesicular-or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton
pumps comprised of a cytoplasmic V 1 complex for ATP hydrolysis and a membrane …
pumps comprised of a cytoplasmic V 1 complex for ATP hydrolysis and a membrane …
Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry
DS Chorev, LA Baker, D Wu, V Beilsten-Edmands… - Science, 2018 - science.org
Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
for study, which often compromises their integrity. In this work, we ejected intact assemblies …
Mass spectrometry of intact membrane protein complexes
Mass spectrometry (MS) of intact soluble protein complexes has emerged as a powerful
technique to study the stoichiometry, structure-function and dynamics of protein assemblies …
technique to study the stoichiometry, structure-function and dynamics of protein assemblies …
Membrane protein–lipid interactions probed using mass spectrometry
Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …
molecules that surround them play crucial roles in maintaining their full structural and …
High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies
The analysis of intact protein assemblies in native-like states by mass spectrometry offers a
wealth of information on their biochemical and biophysical properties. Here we show that the …
wealth of information on their biochemical and biophysical properties. Here we show that the …