Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Mass spectrometry is a vital tool for molecular characterization, and the allied technique of
ion mobility is enhancing many areas of (bio) chemical analysis. Strong synergy arises …

The antioxidant and anti-inflammatory mechanisms of action of flavonoids in lotus plumule
were systematically analyzed using radical scavenging assays and ELISA kits. By this …

Vesicular-or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-driven proton
pumps comprised of a cytoplasmic V 1 complex for ATP hydrolysis and a membrane …

Membrane proteins reside in lipid bilayers and are typically extracted from this environment
for study, which often compromises their integrity. In this work, we ejected intact assemblies …

Mass spectrometry (MS) of intact soluble protein complexes has emerged as a powerful
technique to study the stoichiometry, structure-function and dynamics of protein assemblies …

Membrane proteins that exist in lipid bilayers are not isolated molecular entities. The lipid
molecules that surround them play crucial roles in maintaining their full structural and …

The analysis of intact protein assemblies in native-like states by mass spectrometry offers a
wealth of information on their biochemical and biophysical properties. Here we show that the …