Objectives To perform a systematic literature review (SLR) concerning the safety of synthetic
(s) and biological (b) disease-modifying anti rheumatic dugs (DMARDs) to inform the 2019 …

The coexistence of immune-mediated inflammatory diseases with depression has long been
recognised. Data that illustrate the intimate associations between peripheral and brain …

Interleukein-6 (IL-6), is produced locally from infectious or injured lesions and is delivered to
the whole body via the blood stream, promptly activating the host defense system to perform …

Awareness of a bidirectional relationship between depression and RA through a
biopsychosocial framework may assist clinicians in maintaining an appropriate index of …

Background Rheumatoid arthritis (RA) and depression are conditions which commonly co-
exist. Recent longitudinal studies now suggest a bidirectional association between these …

Introduction: Most arthritides are associated with pain and psychological distress (clinically
significant depression and anxiety). Pain and depression are mutually exacerbating; both …

Depression is a common and disabling comorbidity in rheumatoid arthritis that not only
decreases the likelihood of remission and treatment adherence but also increases the risk of …

Depressive symptoms are reported by more than 20% of people with inflammatory bowel
disease (IBD), while sleep difficulties and fatigue are even more common. Co-morbid …

Pain, fatigue, and physical activity are major determinants of life quality in rheumatoid
arthritis (RA). Janus kinase (JAK) inhibitors have emerged as effective medications in RA …

Chronic pain is a common symptom in rheumatic diseases, and the patient with pain and no
signs of inflammation poses a challenge to the physician. Notably, all rheumatic diseases …