The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Primary tumors are drivers of pre-metastatic niche formation, but the coordination by the
secondary organ toward metastatic dissemination is underappreciated. Here, by single-cell …

Idiopathic pulmonary fibrosis (IPF) is a progressive, and ultimately fatal, chronic interstitial
lung disease characterized by enhanced extracellular matrix deposition. Repetitive alveolar …

Interstitial lung diseases (ILDs), which can arise from a broad spectrum of distinct
aetiologies, can manifest as a pulmonary complication of an underlying autoimmune and …

Interleukins, a group of cytokines participating in inflammation and immune response, are
proved to be involved in the formation and development of pulmonary fibrosis. In this article …

Cancer-associated fibroblasts (CAF) represent a functionally heterogeneous population of
activated fibroblasts that constitutes a major component of tumor stroma. Although CAFs …

The pathogenesis of lung fibrosis involves hyperactivation of innate and adaptive immune
pathways that release inflammatory cytokines and growth factors such as tumor growth …

Neutrophil extracellular traps (NETs) arise from the release of granular and nuclear contents
of neutrophils in the extracellular space in response to different classes of microorganisms …

Mesenchymal stromal/stem cell (MSC) therapy has shown promise in experimental models
of idiopathic pulmonary fibrosis (IPF). The aim of this study was to test the therapeutic effects …