Principles of odor coding in vertebrates and artificial chemosensory systems

I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …

[HTML][HTML] Odor coding in the mammalian olfactory epithelium

SM Kurian, RG Naressi, D Manoel, AS Barwich… - Cell and Tissue …, 2021 - Springer
Noses are extremely sophisticated chemical detectors allowing animals to use scents to
interpret and navigate their environments. Odor detection starts with the activation of odorant …

[HTML][HTML] ER stress transforms random olfactory receptor choice into axon targeting precision

HJ Shayya, JK Kahiapo, R Duffié, KS Lehmann… - Cell, 2022 - cell.com
Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …

[HTML][HTML] Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor …

H Wu, J Zhang, F Jian, JP Chen, Y Zheng, L Tan… - Nature …, 2024 - nature.com
The simultaneous measurement of three-dimensional (3D) genome structure and gene
expression of individual cells is critical for understanding a genome's structure–function …

[HTML][HTML] Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli

KW Zhu, SD Burton, MH Nagai, JD Silverman… - Nature …, 2022 - nature.com
Sensory processing in olfactory systems is organized across olfactory bulb glomeruli,
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …

Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems

L Tan, D Xing, N Daley, XS Xie - Nature structural & molecular biology, 2019 - nature.com
Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we
report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution …

[HTML][HTML] Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice

EV Bashkirova, N Klimpert, K Monahan, CE Campbell… - Elife, 2023 - elifesciences.org
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity,
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …

[HTML][HTML] The zonal organization of odorant receptor gene choice in the main olfactory epithelium of the mouse

B Zapiec, P Mombaerts - Cell reports, 2020 - cell.com
A mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) typically
expresses one allele of one odorant receptor (OR) gene. It is widely thought that the great …

Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system

A Pourmorady, S Lomvardas - Current Opinion in Genetics & Development, 2022 - Elsevier
The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …

Olfactory receptor genes make the case for inter-chromosomal interactions

E Bashkirova, S Lomvardas - Current opinion in genetics & development, 2019 - Elsevier
The partitioning of the interphase nucleus into chromosome territories generally precludes
DNA from making specific and reproducible inter-chromosomal contacts. However, with the …