Principles of odor coding in vertebrates and artificial chemosensory systems
I Manzini, D Schild, C Di Natale - Physiological reviews, 2022 - journals.physiology.org
The biological olfactory system is the sensory system responsible for the detection of the
chemical composition of the environment. Several attempts to mimic biological olfactory …
chemical composition of the environment. Several attempts to mimic biological olfactory …
[HTML][HTML] Odor coding in the mammalian olfactory epithelium
Noses are extremely sophisticated chemical detectors allowing animals to use scents to
interpret and navigate their environments. Odor detection starts with the activation of odorant …
interpret and navigate their environments. Odor detection starts with the activation of odorant …
[HTML][HTML] ER stress transforms random olfactory receptor choice into axon targeting precision
HJ Shayya, JK Kahiapo, R Duffié, KS Lehmann… - Cell, 2022 - cell.com
Olfactory sensory neurons (OSNs) convert the stochastic choice of one of> 1,000 olfactory
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …
receptor (OR) genes into precise and stereotyped axon targeting of OR-specific glomeruli in …
[HTML][HTML] Simultaneous single-cell three-dimensional genome and gene expression profiling uncovers dynamic enhancer connectivity underlying olfactory receptor …
The simultaneous measurement of three-dimensional (3D) genome structure and gene
expression of individual cells is critical for understanding a genome's structure–function …
expression of individual cells is critical for understanding a genome's structure–function …
[HTML][HTML] Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli
Sensory processing in olfactory systems is organized across olfactory bulb glomeruli,
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …
wherein axons of peripheral sensory neurons expressing the same olfactory receptor co …
Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems
Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we
report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution …
report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution …
[HTML][HTML] Opposing, spatially-determined epigenetic forces impose restrictions on stochastic olfactory receptor choice
EV Bashkirova, N Klimpert, K Monahan, CE Campbell… - Elife, 2023 - elifesciences.org
Olfactory receptor (OR) choice represents an example of genetically hardwired stochasticity,
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …
where every olfactory neuron expresses one out of~ 2000 OR alleles in the mouse genome …
[HTML][HTML] The zonal organization of odorant receptor gene choice in the main olfactory epithelium of the mouse
B Zapiec, P Mombaerts - Cell reports, 2020 - cell.com
A mature olfactory sensory neuron (OSN) of the main olfactory epithelium (MOE) typically
expresses one allele of one odorant receptor (OR) gene. It is widely thought that the great …
expresses one allele of one odorant receptor (OR) gene. It is widely thought that the great …
Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system
A Pourmorady, S Lomvardas - Current Opinion in Genetics & Development, 2022 - Elsevier
The mammalian genome possesses> 2000 olfactory receptor (OR) alleles regulated by 63
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …
known OR-Enhancer elements, yet each olfactory sensory neuron (OSN) expresses only a …
Olfactory receptor genes make the case for inter-chromosomal interactions
E Bashkirova, S Lomvardas - Current opinion in genetics & development, 2019 - Elsevier
The partitioning of the interphase nucleus into chromosome territories generally precludes
DNA from making specific and reproducible inter-chromosomal contacts. However, with the …
DNA from making specific and reproducible inter-chromosomal contacts. However, with the …