Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

BACKGROUND The ultimate goal of synthetic chemistry is the efficient assembly of
molecules from readily available starting materials with minimal waste generation. The …

Conspectus Enolate alkylation and conjugate addition into an α, β-unsaturated system have
served as long-standing strategic disconnections for the installation of α-or β-substituents on …

Conspectus C–H activation and functionalization are on the forefront of modern synthetic
chemistry. Imagine if any C–H bond of a molecule could be converted to a C–X bond, where …

C–H functionalization is a very active research field that has attracted the interest of
scientists from many disciplines. This Outlook describes the collaborative efforts within the …

C (sp3)–H and C (sp2)–H glycosylations of structurally complex amino acids and peptides
were accomplished through the assistance of triazole peptide-isosteres. The palladium …

Here we report a novel Rh-catalyzed C− H/C− H alkenylation of N-arylmethanimines with
vinylene carbonate acting as a vinylene unit. Forty examples of C3, C4-nonsubstituted …

Quasi-classical molecular dynamics (MD) simulations were carried out to study the
mechanism of iron porphyrin-catalyzed hydroxylation of ethylbenzene. The hydrogen atom …

Chiral molecules are ubiquitous in nature and play an important role in natural products,
pharmaceuticals, agriculture, advanced materials, as well as living organisms. Therefore …

The use of directing groups allows high levels of selectivity to be achieved in transition metal‐
catalyzed transformations. Efficient removal of these auxiliaries after successful …