The worldwide spread of carbapenem-and polymyxin-resistant Enterobacterales represents
an urgent public-health threat. However, for most countries in the Americas, the available …

Background Colistin belongs to the last-resort antibiotics. The discovery of plasmid-bound
colistin resistance mediated by the mcr-gene (s) is of great concern because, given its …

Antimicrobial susceptibility testing (AST) of cefiderocol poses challenges because of its
unique mechanism of action (ie, requiring an iron-depleted state) and due to differences in …

Carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CR-PA)
producing metallo-β-lactamases (MBLs) cause severe nosocomial infections with no defined …

Due to limited therapeutic options, there is a clinical need to assess the in vitro activity of the
combination of aztreonam (ATM) and ceftazidime-avibactam (CZA) to guide the therapeutic …

Introduction: Increasing occurrence of infections caused by multidrug-resistant Gram-
negative bacteria resulted in colistin being the last agent for treatment. Apart from plasmid …

BACKGROUND Gut decontamination (GD) can decrease the incidence and severity of acute
graft-versus-host disease (aGVHD) in murine models of allogeneic hematopoietic cell …

Polymyxins are used as treatments of last resort for Gram-negative bacterial infections. Their
increased use has led to concerns about emerging polymyxin resistance (PR). Phenotypic …

Carbapenemases-producing K. pneumoniae are challenging antimicrobial therapy of
hospitalised patients, which is further complicated by colistin resistance. The aim of this …

The treatment of infections caused by carbapenem-resistant Enterobacterales, especially
New Delhi metallo-β-lactamase (NDM)-producing bacteria, is challenging. Although less …