Numerous studies have demonstrated the presence of cancer stem cells (CSCs) within solid
tumors. Although the precursor of these cells is not clearly established, recent studies …

Abstract The Solute Carrier 1A (SLC1A) family includes two major mammalian transport
systems—the alanine serine cysteine transporters (ASCT1-2) and the human glutamate …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

The cellular phenotype is described by a complex network of molecular interactions.
Elucidating network properties that distinguish disease from the healthy cellular state is …

Abstract The Cancer Genome Atlas (TCGA) has accrued RNA-Seq-based transcriptome
data for more than 4000 cancer tissue samples across 12 cancer types, translating these …

A more complete understanding of aberrant oncogenic signaling in neuroblastoma, a
malignancy of the developing sympathetic nervous system, is paramount to improving …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

Cancer cells are metabolically reprogrammed to support their high rates of proliferation,
continuous growth, survival, invasion, metastasis, and resistance to cancer treatments …

Purpose: Deregulated MYC drives oncogenesis in many tissues yet direct pharmacologic
inhibition has proven difficult. MYC coordinately regulates polyamine homeostasis as these …

Aurora kinases play critical roles in regulating spindle assembly, chromosome segregation,
and cytokinesis to ensure faithful segregation of chromosomes during mitotic cell division …