Modular Synthetic Platform to Tailor Therapeutic-Specific Delivery in Injectable Hydrogels

JHM Wong, B Sim, C Owh, V Ow, VTA Teo… - … Applied Materials & …, 2024 - ACS Publications
Injectable thermoresponsive hydrogels (thermogels), valued for their conformability and
minimal invasiveness, are increasingly used as in situ forming implants for drug delivery and …

Sustained release of brimonidine from a new composite drug delivery system for treatment of glaucoma

J Sun, Y Lei, Z Dai, X Liu, T Huang, J Wu… - … applied materials & …, 2017 - ACS Publications
A novel layered double hydroxide (LDH) nanoparticle/thermogel composite drug delivery
system (DDS) for sustained release of brimonidine (Bri) has been designed, prepared, and …

Gold nanoparticle-functionalized reverse thermal gel for tissue engineering applications

B Peña, M Maldonado, AJ Bonham… - … applied materials & …, 2019 - ACS Publications
Utilizing polymers in cardiac tissue engineering holds promise for restoring function to the
heart following myocardial infarction, which is associated with grave morbidity and mortality …

Injectable carbon nanotube-functionalized reverse thermal gel promotes cardiomyocytes survival and maturation

B Peña, S Bosi, BA Aguado, D Borin… - … applied materials & …, 2017 - ACS Publications
The ability of the adult heart to regenerate cardiomyocytes (CMs) lost after injury is limited,
generating interest in developing efficient cell-based transplantation therapies. Rigid carbon …

Injectable polymeric delivery system for spatiotemporal and sequential release of therapeutic proteins to promote therapeutic angiogenesis and reduce inflammation

AJ Rocker, DJ Lee, R Shandas… - ACS biomaterials science …, 2020 - ACS Publications
Myocardial infarction (MI) causes cardiac cell death, induces persistent inflammatory
responses, and generates harmful pathological remodeling, which leads to heart failure …

Hereditary Optic Neuropathies: A Systematic Review on the Interplay between Biomaterials and Induced Pluripotent Stem Cells

M Ladero, JA Reche-Sainz, ME Gallardo - Bioengineering, 2024 - mdpi.com
Hereditary optic neuropathies (HONs) such as dominant optic atrophy (DOA) and Leber
Hereditary Optic Neuropathy (LHON) are mitochondrial diseases characterized by a …

Inputs of macromolecular engineering in the design of injectable hydrogels based on synthetic thermoresponsive polymers

V Pertici, T Trimaille, D Gigmes - Macromolecules, 2020 - ACS Publications
Injectable hydrogels have received high attention over the last decades in drug delivery and
tissue engineering as they allow minimal invasive procedures. Among them …

An injectable sulfonated reversible thermal gel for therapeutic angiogenesis to protect cardiac function after a myocardial infarction

DJ Lee, MA Cavasin, AJ Rocker, DE Soranno… - Journal of biological …, 2019 - Springer
Background Cardiovascular disease and myocardial infarction are associated with high
mortality and morbidity and a more effective treatment remains a major clinical need. The …

Polybenzyl glutamate biocompatible scaffold promotes the efficiency of retinal differentiation toward retinal ganglion cell lineage from human-induced pluripotent stem …

TC Chen, PY She, DF Chen, JH Lu, CH Yang… - International journal of …, 2019 - mdpi.com
Optic neuropathy is one of the leading causes of irreversible blindness caused by retinal
ganglion cell (RGC) degeneration. The development of induced pluripotent stem cell (iPSC) …

Injectable neurotrophic factor delivery system supporting retinal ganglion cell survival and regeneration following optic nerve crush

MR Laughter, JR Bardill, DA Ammar… - ACS biomaterials …, 2018 - ACS Publications
In general, neurons belonging to the central nervous system (CNS), such as retinal ganglion
cells (RGCs), do not regenerate. Due to this, strategies have emerged aimed at protecting …