Abstract TFF1/pS2, TFF2/SP and TFF3/ITF are soluble peptides with trefoil domain (s) and C-
terminal dimerization domain, which are conserved among human, cow, mouse and rat …

The GATA family of transcription factors participates in gastrointestinal (GI) development.
Increases in GATA-4 and-5 expression occur in differentiation and GATA-6 expression in …

Intestinal metaplasia (IM) is part of a stepwise sequence of alterations of the gastric mucosa,
leading ultimately to gastric cancer, and is strongly associated with chronic Helicobacter …

Intestinal mucin gene MUC2 is abundantly expressed in goblet cells. To identify the
transcriptional activator that regulates goblet-specific expression of MUC2, we analyzed the …

Gastric cancer may appear by frequent genetic or epigenetic changes in oncogenes, tumor
suppressor or DNA mismatch repair genes. Molecular studies show the possibility of …

The roles of CDX2 and CDX1 homeobox genes during gastric carcinogenesis remain poorly
defined. We have studied the expression of CDX2/1 in gastric cancers and intestinal …

Abstract SOX2, a SRY-related HMG box protein, is thought to be an important transcription
factor during organogenesis, including the stomach although the expression and function …

In intestinal metaplasia and 30% of gastric carcinomas, MUC2 intestinal mucin and the
intestine-specific transcription factors Cdx-1 and Cdx-2 are aberrantly expressed. The …

Intestinal metaplasia is a key event in multistep gastric carcinogenesis. CDX2, a master
regulator of intestinal phenotype, was shown to play a tumor-suppressive role in colon …

Purpose: In lung cancer, DNA hypermethylation is known to be a common event.
Experimental Design: Gene expression and methylation status of GATA-4, GATA-5, and …