The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …

The axolotl is one of the few tetrapods that are capable of regenerating complicated
biological structures, such as complete limbs, throughout adulthood. Upon injury the axolotl …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Evolutionary modification has produced a spectrum of animal defence traits to escape
predation, including the ability to autotomize body parts to elude capture,. After autotomy, the …

BACKGROUND: Regenerative medicine is a medical subspecialty that seeks to recruit and
enhance the body's own inherent healing armamentarium in the treatment of patient …

Limb regeneration is a frontier in biomedical science. Identifying triggers of innate
morphogenetic responses in vivo to induce the growth of healthy patterned tissue would …

Studying regeneration in animals where and when it occurs is inherently interesting and a
challenging research topic within developmental biology. Historically, vertebrate …

Amputation of the distal region of the terminal phalanx of mice causes an initial wound
healing response followed by blastema formation and the regeneration of the digit tip. Thus …

De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …

The regenerating digit tip of mice is a novel epimorphic response in mammals that is similar
to fingertip regeneration in humans. Both display restricted regenerative capabilities that are …