Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Motor proteins are key players in exerting spatiotemporal control over the intracellular
location of membrane-bound compartments, including endosomes containing cargo. In this …

Smart conversion of supramolecular structures in vivo is an attractive strategy in cancer
nanomedicine, which is usually achieved via specific peptide sequences. Here we …

Macropinocytosis mediates the non-selective bulk uptake of extracellular fluid, enabling
cells to survey the environment and obtain nutrients. A conserved set of signaling proteins …

Membrane-associated proteins are important membrane readers that mediate and facilitate
the signaling and trafficking pathways in eukaryotic membrane-bound compartments. The …

Ebola (EBOV) and Marburg viruses (MARV) cause severe hemorrhagic fever associated
with high mortality rates in humans. A better understanding of filovirus-host interactions that …

NLRP3 is an inflammasome-forming protein that plays a key role in conditions ranging from
infections to Alzheimer's disease. NLRP3 is activated by many potassium (K+)-dependent or …

PLEKHF2 proteins are widespread in animals, but their functions and mechanisms remain
poorly defined. Here we clearly demonstrate that PLEKHF2 is a newly identified present …

Interest in macropinocytosis has risen in recent years owing to its function in tumorigenesis,
immune reaction, and viral infection. Cancer cells utilize macropinocytosis to acquire …