P2X7 promotes metastatic spreading and triggers release of miRNA-containing exosomes and microvesicles from melanoma cells

A Pegoraro, E De Marchi, M Ferracin, E Orioli… - Cell death & …, 2021 - nature.com
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as
microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor …

Getting under the skin: The role of CDK4/6 in melanomas

L Guo, J Qi, H Wang, X Jiang, Y Liu - European Journal of Medicinal …, 2020 - Elsevier
Melanoma is the deadliest type of cancer that affects the largest organ of our body, the skin.
In recent years, there is an increase in the incidence and aggressiveness of melanomas …

Malignant melanoma: autoimmunity and supracellular messaging as new therapeutic approaches

IG Motofei - Current Treatment Options in Oncology, 2019 - Springer
Opinion statement Melanoma is one of the most aggressive forms of cancer, with a high
mortality rate in the absence of a safe and curable therapy. As a consequence, several …

Handling imbalanced class in melanoma: Kemeny–Young rule based optimal rank aggregation and Self-Adaptive Differential Evolution Optimization

G Srivastava, N Pradhan - Engineering Applications of Artificial Intelligence, 2023 - Elsevier
Melanoma, despite its relatively low incidence compared to other types of skin cancer,
accounts for a significant proportion of skin cancer-related deaths. Early detection of …

Circulating CD56bright NK cells inversely correlate with survival of melanoma patients

K de Jonge, A Ebering, S Nassiri, H Maby-El Hajjami… - Scientific reports, 2019 - nature.com
The roles of NK cells in human melanoma remain only partially understood. We
characterized NK cells from peripheral blood ex vivo by flow cytometry obtained from late …

Long‐term survival among 5‐year survivors of adolescent and young adult cancer

AM Berkman, JA Livingston, K Merriman… - Cancer, 2020 - Wiley Online Library
Background Although there are a growing number of survivors of adolescent and young
adult (AYA) cancer, to the authors' knowledge the long‐term overall survival (OS) patterns …

Sanggenol L promotes apoptotic cell death in melanoma skin cancer cells through activation of caspase cascades and apoptosis-inducing factor

YS Won, KI Seo - Food and Chemical Toxicology, 2020 - Elsevier
Sanggenol L is one component of root bark of Morus alba. The molecular and cellular
mechanisms of sanggenol L effects on melanoma cells are not well known. Recently …

Deep-learning-based survival prediction of patients with cutaneous malignant melanoma

H Yu, W Yang, S Wu, S Xi, X Xia, Q Zhao… - Frontiers in …, 2023 - frontiersin.org
Background This study obtained data on patients with cutaneous malignant melanoma
(CMM) from the Surveillance, Epidemiology, and End Results (SEER) database, and used a …

Bioorthogonal targeted cell membrane vesicles/cell-sheet composites reduce postoperative tumor recurrence and scar formation of melanoma

X Yang, Z Xu, F Shu, J Xiao, Y Zeng, X Lu, F Yu… - Journal of Controlled …, 2024 - Elsevier
While surgical resection is the predominant clinical strategy in the treatment of melanoma,
postoperative recurrence and undetectable metastasis are both pernicious drawbacks to this …

Cost items in melanoma patients by clinical characteristics and time from diagnosis

A Buja, C Cozzolino, A Zanovello, R Geppini… - Frontiers in …, 2023 - frontiersin.org
Background Costs related to the care of melanoma patients have been rising over the past
few years due to increased disease incidence as well as the introduction of innovative …