A guide to membraneless organelles and their various roles in gene regulation

T Hirose, K Ninomiya, S Nakagawa… - … Reviews Molecular Cell …, 2023 - nature.com
Membraneless organelles (MLOs) are detected in cells as dots of mesoscopic size. By
undergoing phase separation into a liquid-like or gel-like phase, MLOs contribute to …

Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

LNCcation: lncRNA localization and function

MC Bridges, AC Daulagala, A Kourtidis - Journal of Cell Biology, 2021 - rupress.org
Subcellular localization of RNAs has gained attention in recent years as a prevalent
phenomenon that influences numerous cellular processes. This is also evident for the large …

Intracellular mRNA transport and localized translation

S Das, M Vera, V Gandin, RH Singer… - Nature reviews Molecular …, 2021 - nature.com
Fine-tuning cellular physiology in response to intracellular and environmental cues requires
precise temporal and spatial control of gene expression. High-resolution imaging …

Mammalian stress granules and P bodies at a glance

CL Riggs, N Kedersha, P Ivanov… - Journal of cell …, 2020 - journals.biologists.com
Stress granules (SGs) and processing bodies (PBs) are membraneless ribonucleoprotein-
based cellular compartments that assemble in response to stress. SGs and PBs form …

Formation, function, and pathology of RNP granules

N Ripin, R Parker - Cell, 2023 - cell.com
Ribonucleoprotein (RNP) granules are diverse membrane-less organelles that form through
multivalent RNA-RNA, RNA-protein, and protein-protein interactions between RNPs. RNP …

Higher-order organization of biomolecular condensates

CM Fare, A Villani, LE Drake, J Shorter - Open biology, 2021 - royalsocietypublishing.org
A guiding principle of biology is that biochemical reactions must be organized in space and
time. One way this spatio-temporal organization is achieved is through liquid–liquid phase …

Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer

A Parolia, M Cieslik, SC Chu, L Xiao, T Ouchi, Y Zhang… - Nature, 2019 - nature.com
Abtract Forkhead box A1 (FOXA1) is a pioneer transcription factor that is essential for the
normal development of several endoderm-derived organs, including the prostate gland …

Illuminating RNA biology through imaging

P Le, N Ahmed, GW Yeo - Nature cell biology, 2022 - nature.com
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid–liquid phase separation

AM Ladouceur, BS Parmar… - Proceedings of the …, 2020 - National Acad Sciences
Once described as mere “bags of enzymes,” bacterial cells are in fact highly organized, with
many macromolecules exhibiting nonuniform localization patterns. Yet the physical and …