Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …

Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

Currently, renal cell carcinoma (RCC) is the most prevalent type of kidney cancer. Targeted
therapy has replaced radiation therapy and chemotherapy as the main treatment option for …

Myeloid-derived suppressor cells (MDSC) are important regulators of immune responses in
cancer. They represent a relatively stable form of pathologic activation of neutrophils and …

Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune
responses in cancer and other pathological conditions. In recent years, ample evidence …

Neutrophils are indispensable antagonists of microbial infection and facilitators of wound
healing. In the cancer setting, a newfound appreciation for neutrophils has come into view …

Myeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid
cells that have potent immune-suppressive activity. Studies in both mice and humans have …

Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding …

Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is
becoming increasingly complex. In addition to their eponymous role in suppressing immune …

Among the various immunological and non-immunological tumor-promoting activities of
myeloid-derived suppressor cells (MDSCs), their immunosuppressive capacity remains a …