Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates
the protein and lipid content of the plasma membrane, it participates in the intracellular …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Vesicular transport driven by membrane trafficking systems conserved in eukaryotes is
critical to cellular functionality and homeostasis. It is known that homotypic fusion and …

Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between
membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of …

Rab7 promotes fusion of autophagosomes and late endosomes with lysosomes in yeast and
metazoan cells, acting together with its effector, the tethering complex HOPS. Here we show …

The autophagosomal SNARE Syntaxin17 (Syx17) forms a complex with Snap29 and
Vamp7/8 to promote autophagosome-lysosome fusion via multiple interactions with the …

Obesity-related renal lipotoxicity and chronic kidney disease (CKD) are prevalent
pathologies with complex aetiologies. One hallmark of renal lipotoxicity is the ectopic …

Autophagy is a catabolic process in eukaryotic cells promoting bulk or selective degradation
of cellular components within lysosomes. In recent decades, several model systems were …

At the onset of metamorphosis, Drosophila salivary gland cells undergo a burst of glue
granule secretion to attach the forming pupa to a solid surface. Here, we show that excess …