It is now well established that cardiovascular disease contributes significantly to both
morbidity and mortality in COPD. Shared risk factors for cardiovascular disease and COPD …

The management of chronic obstructive pulmonary disease (COPD) is fundamentally still
heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a …

Rationale: Proteolysis is a key aspect of the lung's innate immune system. Proteases,
including neutrophil elastase and MMPs (matrix metalloproteases), modulate cell signaling …

When exposed to a specific microenvironment, macrophages acquire either M1-or M2-
polarized phenotypes associated with inflammation and tissue remodeling, respectively …

Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …

The inflammatory responses in chronic airway diseases leading to emphysema are not fully
defined. We hypothesised that lung eosinophilia contributes to airspace enlargement in a …

Rationale: The airflow limitation that defines severity of chronic obstructive pulmonary
disease (COPD) is caused by a combination of small airway obstruction and …

Diseases of accelerated aging often occur together (multimorbidity), and their prevalence is
increasing, with high societal and health care costs. Chronic obstructive pulmonary disease …

COPD is characterized by increased cough, mucus production, and airway inflammation.
Beating epithelial cell cilia contribute to mucociliary clearance with ciliary beat frequency …

Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …