Maintaining metabolic homeostasis is essential for cellular and organismal health
throughout life. Multiple signaling pathways that regulate metabolism also play critical roles …

Deregulation of protein post-translational modifications is intensively involved in the etiology
of diseases, including degenerative diseases, inflammatory injuries, and cancers …

Background & Aims The liver is a metabolically active organ and is also 'tolerogenic',
exhibiting sophisticated mechanisms of immune regulation that prevent pathogen attacks …

Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase primarily located in
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …

Melanoma is recognized as the most dangerous type of skin cancer, with high mortality and
resistance to currently used treatments. To overcome the limitations of the available …

Sirtuin 5 (SIRT5) is a predominantly mitochondrial enzyme catalyzing the removal of glutaryl,
succinyl, malonyl, and acetyl groups from lysine residues through a NAD+-dependent …

The sirtuin family comprises seven NAD+‐dependent enzymes which catalyze protein lysine
deacylation and mono ADP‐ribosylation. Sirtuins act as central regulators of genomic …

Abstract Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase. It is emerging as a
promising target for the development of drugs to treat cancer and metabolism-related …

Sirtuins (SIRTs) are well-known as nicotinic adenine dinucleotide+ (NAD+)-dependent
histone deacetylases, which are important epigenetic enzymes consisting of seven family …

Sirtuins use NAD+ to remove various acyl groups from protein lysine residues. Through
working on different substrate proteins, they display many biological functions, including …