Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Isocitrate dehydrogenase (IDH) is the key metabolic enzyme that catalyzes the conversion of
isocitrate to α-ketoglutarate (α-KG). Two main types of IDH1 and IDH2 are present in …

Abstract Isocitrate dehydrogenase (IDH) 1 and 2 mutations result in overproduction of D-2-
hydroxyglutarate (2-HG) and impaired cellular differentiation. Ivosidenib, a targeted mutant …

Glioma is one of the most common types of brain tumors, and its high recurrence and
mortality rates threaten human health. In 2008, the frequent isocitrate dehydrogenase 1 …

Mutations at the arginine residue (R132) in isocitrate dehydrogenase 1 (IDH1) are frequently
identified in various human cancers. Inhibition of mutant IDH1 (mIDH1) with small molecules …

Isocitrate dehydrogenases 1 and 2 (IDH1, 2), the key Krebs cycle enzymes that generate
NADPH reducing equivalents, undergo heterozygous mutations in> 70% of low-to mid …

Mutations in IDH genes occur frequently in acute myeloid leukemia (AML) and other human
cancers to generate the oncometabolite R-2HG. Allosteric inhibition of mutant IDH …

A stereo-and regioselective 1, 3-dipolar cycloaddition of the stable ninhydrin-derived
azomethine ylide [2-(3, 4-dihydro-2 H-pyrrolium-1-yl)-1-oxo-1 H-inden-3-olate, DHPO] to …

A highly diastereo-and enantioselective desymmetrization of prochiral cyclopropenes via a
Cu (CH3CN) 4BF4/Ph-Phosferrox complex catalyzed 1, 3-dipolar cycloaddition of …

Reprogramming of energy metabolism is one of the basic characteristics of cancer and has
been proved to be an important cancer treatment strategy. Isocitrate dehydrogenases (IDHs) …