Ancient pathogen genomics as an emerging tool for infectious disease research

MA Spyrou, KI Bos, A Herbig, J Krause - Nature Reviews Genetics, 2019 - nature.com
Over the past decade, a genomics revolution, made possible through the development of
high-throughput sequencing, has triggered considerable progress in the study of ancient …

[图书][B] The archaeology of human bones

S Mays - 2021 - taylorfrancis.com
The Archaeology of Human Bones provides an up to date account of the analysis of human
skeletal remains from archaeological sites, introducing students to the anatomy of bones …

[HTML][HTML] Ancient genomes reveal a high diversity of Mycobacterium leprae in medieval Europe

VJ Schuenemann, C Avanzi, B Krause-Kyora… - PLoS …, 2018 - journals.plos.org
Studying ancient DNA allows us to retrace the evolutionary history of human pathogens,
such as Mycobacterium leprae, the main causative agent of leprosy. Leprosy is one of the …

[HTML][HTML] Ancient genomes reveal structural shifts after the arrival of Steppe-related ancestry in the Italian Peninsula

T Saupe, F Montinaro, C Scaggion, N Carrara… - Current Biology, 2021 - cell.com
Across Europe, the genetics of the Chalcolithic/Bronze Age transition is increasingly
characterized in terms of an influx of Steppe-related ancestry. The effect of this major shift on …

One Health Approaches to Trace Mycobacterium leprae's Zoonotic Potential Through Time

C Urban, AA Blom, S Pfrengle… - Frontiers in …, 2021 - frontiersin.org
Hansen's disease (leprosy), mainly caused by infection with Mycobacterium leprae, has
accompanied humanity for thousands of years. Although currently rare in Europe, there are …

2000-year-old pathogen genomes reconstructed from metagenomic analysis of Egyptian mummified individuals

J Neukamm, S Pfrengle, M Molak, A Seitz, M Francken… - BMC biology, 2020 - Springer
Background Recent advances in sequencing have facilitated large-scale analyses of the
metagenomic composition of different samples, including the environmental microbiome of …

Multi-omic detection of Mycobacterium leprae in archaeological human dental calculus

AK Fotakis, SD Denham, M Mackie… - … of the Royal …, 2020 - royalsocietypublishing.org
Mineralized dental plaque (calculus) has proven to be an excellent source of ancient
biomolecules. Here we present a Mycobacterium leprae genome (6.6-fold), the causative …

Infectious diseases and Neolithic transformations: Evaluating biological and archaeological proxies in the German loess zone between 5500 and 2500 BCE

K Fuchs, C Rinne, C Drummer, A Immel… - The …, 2019 - journals.sagepub.com
It is a common assumption that–compared with the Mesolithic–the adoption of Neolithic
lifeways was accompanied by a higher risk of infection and the development of epidemic …

Mycobacterium leprae diversity and population dynamics in medieval Europe from novel ancient genomes

S Pfrengle, J Neukamm, M Guellil, M Keller, M Molak… - BMC biology, 2021 - Springer
Background Hansen's disease (leprosy), widespread in medieval Europe, is today mainly
prevalent in tropical and subtropical regions with around 200,000 new cases reported …

Evolutionary history of Mycobacterium leprae in the Pacific Islands

KE Blevins, AE Crane, C Lum… - … of the Royal …, 2020 - royalsocietypublishing.org
As one of the oldest known human diseases, leprosy or Hansen's disease remains a public
health concern around the world with over 200 000 new cases in 2018. Most human leprosy …