Huntington's disease (HD) is a fatal and pure genetic disease with a progressive loss of
medium spiny neurons (MSN). HD is caused by expanded polyglutamine repeats in the …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …

The polyglutamine expansion of huntingtin (mHTT) causes Huntington disease (HD) and
neurodegeneration, but the mechanisms remain unclear. Here, we found that mHtt promotes …

Huntington disease (HD) is caused by an expansion mutation of the N-terminal
polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable …

The CAG expansion of huntingtin (mHTT) associated with Huntington disease (HD) is a
ubiquitously expressed gene, yet it prominently damages the striatum and cortex, followed …

Tunneling nanotubes (TNT) are thin, membranous, tunnel-like cell-to-cell connections, but
the mechanisms underlying their biogenesis or functional role remains obscure. Here, we …

A major unresolved problem in neurodegenerative disease is why and how a specific set of
neurons in the brain are highly vulnerable to neuronal death. Multiple pathways and …

Huntington disease (HD) is an ideal model for investigating selective neurodegeneration, as
expanded polyQ repeats in the ubiquitously expressed huntingtin (HTT) cause the …

Mitochondrial dysfunction is a central feature of neurodegeneration within the central and
peripheral nervous system, highlighting a strong dependence on proper mitochondrial …

Elimination of dysfunctional mitochondria via mitophagy is essential for cell survival and
neuronal functions. But, how impaired mitophagy participates in tissue-specific vulnerability …