Stress and strain within the lung

L Gattinoni, E Carlesso, P Caironi - Current opinion in critical care, 2012 - journals.lww.com
Stress and strain within the lung : Current Opinion in Critical Care Stress and strain within the
lung : Current Opinion in Critical Care Log in or Register Subscribe to journalSubscribe Get …

Bioactive extracellular matrix fragments in lung health and disease

A Gaggar, N Weathington - The Journal of clinical …, 2016 - Am Soc Clin Investig
The extracellular matrix (ECM) is the noncellular component critical in the maintenance of
organ structure and the regulation of tissue development, organ structure, and cellular …

The mechanical memory of lung myofibroblasts

JL Balestrini, S Chaudhry, V Sarrazy… - Integrative …, 2012 - academic.oup.com
Fibroblasts differentiate into the highly synthetic and contractile myofibroblast phenotype
when exposed to substrates with an elastic modulus corresponding to pathologically stiff …

Algal carbohydrate polymers: Catalytic innovations for sustainable development

S Sahu, S Sharma, A Kaur, G Singh, M Khatri… - Carbohydrate …, 2024 - Elsevier
Algal polysaccharides, harnessed for their catalytic potential, embody a compelling narrative
in sustainable chemistry. This review explores the complex domains of algal carbohydrate …

[HTML][HTML] Mechanics of pulmonary airways: linking structure to function through constitutive modeling, biochemistry, and histology

M Eskandari, TM Nordgren, GD O'Connell - Acta biomaterialia, 2019 - Elsevier
Breathing involves fluid-solid interactions in the lung; however, the lack of experimental data
inhibits combining the mechanics of air flow to airway deformation, challenging the …

Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1

AS Adhikari, J Chai, AR Dunn - Biophysical Journal, 2011 - cell.com
Both mechanotransduction and extracellular matrix (ECM) proteolytic remodeling are critical
during embryonic development and in disease progression. Although mechanical stress is …

Nonlinear elasticity of the lung extracellular microenvironment is regulated by macroscale tissue strain

I Jorba, G Beltrán, B Falcones, B Suki, R Farré… - Acta biomaterialia, 2019 - Elsevier
The extracellular matrix (ECM) of the lung provides physical support and key mechanical
signals to pulmonary cells. Although lung ECM is continuously subjected to different stretch …

Emphysema and mechanical stress-induced lung remodeling

B Suki, S Sato, H Parameswaran, MV Szabari… - …, 2013 - journals.physiology.org
Transpulmonary pressure and the mechanical stresses of breathing modulate many
essential cell functions in the lung via mechanotransduction. We review how mechanical …

[HTML][HTML] Anti-CELA1 antibody KF4 prevents emphysema by inhibiting stretch-mediated remodeling

M Ojha, NJ Smith, AJ Devine, R Joshi, EM Goodman… - JCI insight, 2024 - ncbi.nlm.nih.gov
There are no therapies to prevent emphysema progression. Chymotrypsin-like elastase 1
(CELA1) is a serine protease that binds and cleaves lung elastin in a stretch-dependent …

Computed tomography measure of lung at risk and lung function decline in chronic obstructive pulmonary disease

SP Bhatt, S Bodduluri, EA Hoffman… - American journal of …, 2017 - atsjournals.org
Rationale: The rate of decline of lung function is greater than age-related change in a
substantial proportion of patients with chronic obstructive pulmonary disease, even after …