Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Although the mammalian mtDNA transcription machinery is simple and resembles
bacteriophage systems, there are many reports that nuclear transcription regulators, as …

The human mitochondrial ribosome (mitoribosome) and associated proteins regulate the
synthesis of 13 essential subunits of the oxidative phosphorylation complexes. We report the …

The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet
many molecular details of mitochondrial translation remain elusive. It has been commonly …

The mitochondrial translation machinery highly diverged from its bacterial counterpart. This
includes deviation from the universal genetic code, with AGA and AGG codons lacking …

Background Oxidative phosphorylation (OXPHOS) complexes consist of nuclear and
mitochondrial DNA-encoded subunits. Their biogenesis requires cross-compartment gene …

Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …

Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …

Mitochondria are epicentres of eukaryotic metabolism and bioenergetics. Pioneering efforts
in recent decades have established the core protein componentry of these organelles and …

A stop codon within the mRNA facilitates coordinated termination of protein synthesis,
releasing the nascent polypeptide from the ribosome. This essential step in gene expression …