Clinical and experimental insight into pathophysiology, comorbidity and therapy of absence seizures

V Crunelli, ML Lőrincz, C McCafferty, RC Lambert… - Brain, 2020 - academic.oup.com
Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

Cognitive and neurodevelopmental comorbidities in paediatric epilepsy

KC Nickels, MJ Zaccariello, LD Hamiwka… - Nature Reviews …, 2016 - nature.com
Cognitive and behavioural comorbidities are often seen in children with epilepsy, and are
more common and severe in refractory epilepsy. These comorbidities are associated with …

Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence

AM Kanner, SC Schachter, JJ Barry, DC Hersdorffer… - Epilepsy & Behavior, 2012 - Elsevier
Depression is the most frequent psychiatric comorbidity in people with epilepsy (PWE) with
lifetime prevalence rates ranging between 30 and 35%. Multifactorial variables play a …

Depression and epilepsy: a bidirectional relation?

AM Kanner - Epilepsia, 2011 - Wiley Online Library
A bidirectional relation between depressive disorders and epilepsy has been suggested by
several population‐based studies and is supported by experimental studies. This article …

T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures

E Tringham, KL Powell, SM Cain, K Kuplast… - Science translational …, 2012 - science.org
Absence seizures are a common seizure type in children with genetic generalized epilepsy
and are characterized by a temporary loss of awareness, arrest of physical activity, and …

The WAG/Rij strain: a genetic animal model of absence epilepsy with comorbidity of depressiony

K Sarkisova, G van Luijtelaar - Progress in Neuro-Psychopharmacology …, 2011 - Elsevier
A great number of clinical observations show a relationship between epilepsy and
depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic …

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

BD Semple, A Zamani, G Rayner, SR Shultz… - Neurobiology of …, 2019 - Elsevier
Survivors of traumatic brain injury (TBI) often develop chronic neurological, neurocognitive,
psychological, and psychosocial deficits that can have a profound impact on an individual's …

Issues related to symptomatic and disease‐modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy

AR Brooks‐Kayal, KG Bath, AT Berg… - …, 2013 - Wiley Online Library
Many symptoms of neurologic or psychiatric illness—such as cognitive impairment,
depression, anxiety, attention deficits, and migraine—occur more frequently in people with …

Neuropsychiatric symptomatology predicts seizure recurrence in newly treated patients

S Petrovski, CEI Szoeke, NC Jones, MR Salzberg… - Neurology, 2010 - AAN Enterprises
Objectives: To test the hypothesis that neuropsychiatric symptomatology is predictive of the
success of seizure control in patients newly treated with antiepileptic drugs (AEDs), and that …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …