Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
Immune-mediated (IM) adverse drug reactions (ADRs) are an underrecognized source of
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
preventable morbidity, mortality, and cost. Increasingly, genetic variation in the HLA loci is …
Genetics of autoimmune diseases: insights from population genetics
PS Ramos, AM Shedlock, CD Langefeld - Journal of human genetics, 2015 - nature.com
Human genetic diversity is the result of population genetic forces. This genetic variation
influences disease risk and contributes to health disparities. Autoimmune diseases (ADs) …
influences disease risk and contributes to health disparities. Autoimmune diseases (ADs) …
Gene expression drives local adaptation in humans
HB Fraser - Genome research, 2013 - genome.cshlp.org
The molecular basis of adaptation—and, in particular, the relative roles of protein-coding
versus gene expression changes—has long been the subject of speculation and debate …
versus gene expression changes—has long been the subject of speculation and debate …
Common risk alleles for inflammatory diseases are targets of recent positive selection
Genome-wide association studies (GWASs) have identified hundreds of loci harboring
genetic variation influencing inflammatory-disease susceptibility in humans. It has been …
genetic variation influencing inflammatory-disease susceptibility in humans. It has been …
Immunogenomics of killer cell immunoglobulin-like receptor (KIR) and HLA class I: coevolution and consequences for human health
NR Pollock, GF Harrison, PJ Norman - The Journal of Allergy and Clinical …, 2022 - Elsevier
Interactions of killer cell immunoglobin-like receptors (KIR) with human leukocyte antigens
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
(HLA) class I regulate effector functions of key cytotoxic cells of innate and adaptive …
Influence of HLA on human partnership and sexual satisfaction
The major histocompatibility complex (MHC, called HLA in humans) is an important genetic
component of the immune system. Fish, birds and mammals prefer mates with different …
component of the immune system. Fish, birds and mammals prefer mates with different …
HLA supertype variation across populations: new insights into the role of natural selection in the evolution of HLA-A and HLA-B polymorphisms
R dos Santos Francisco, S Buhler, JM Nunes… - Immunogenetics, 2015 - Springer
Supertypes are groups of human leukocyte antigen (HLA) alleles which bind overlapping
sets of peptides due to sharing specific residues at the anchor positions—the B and F …
sets of peptides due to sharing specific residues at the anchor positions—the B and F …
The HLA‐B landscape of Africa: signatures of pathogen‐driven selection and molecular identification of candidate alleles to malaria protection
Human leukocyte antigen (HLA) genes play a key role in the immune response to infectious
diseases, some of which are highly prevalent in specific environments, like malaria in sub …
diseases, some of which are highly prevalent in specific environments, like malaria in sub …
HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection
S Buhler, JM Nunes, A Sanchez-Mazas - Immunogenetics, 2016 - Springer
The main function of HLA class I molecules is to present pathogen-derived peptides to
cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an …
cytotoxic T lymphocytes. This function is assumed to drive the maintenance of an …
Human and tuberculosis co-evolution: An integrative view
P Perrin - Tuberculosis, 2015 - Elsevier
Tuberculosis (TB) ranks as the second cause of death from an infectious disease worldwide
after HIV. Archaeogenetics and evolutionary scenario for the Mycobacterium tuberculosis …
after HIV. Archaeogenetics and evolutionary scenario for the Mycobacterium tuberculosis …