The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

The fast advances of theranostic nanomedicine enable the rational design and construction
of diverse functional nanoplatforms for versatile biomedical applications, among which gas …

Glutathione (GSH) plays an important role in a multitude of cellular processes, including cell
differentiation, proliferation, and apoptosis, and disturbances in GSH homeostasis are …

Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in
response to a variety of stimuli to degrade heme, which generates the biologically active …

Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Controlled activation is a critical component in prodrug development. Here we report a
concentration-sensitive platform approach for bioorthogonal prodrug activation by taking …

Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic
molecule with important signalling capabilities in physiological and pathophysiological …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Despite the capacity of chaperones and other homeostatic components to restore folding
equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer …

Atherosclerosis is an inflammatory process of the vascular wall characterized by the
infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low-density …