▪ Abstract In the mid to late 1980s, studies were published that provided the first evidence for
the existence of glutamate receptors that are not ligand-gated cation channels but are …

Glutamate receptors (GluRs) mediate most of the excitatory neurotransmission in the
mammalian central nervous system (CNS). In addition, they are involved in plastic changes …

The G protein‐coupled metabotropic glutamate (mGlu) receptors are differentially localized
at various synapses throughout the brain. Depending on the receptor subtype, they appear …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Movement, the fundamental component of behavior and the principal extrinsic action of the
brain, is produced when skeletal muscles contract and relax in response to patterns of action …

The activity of the GABAergic neurons of the thalamic reticular nucleus (TRN) has long been
known to play important roles in modulating the flow of information through the thalamus and …

The metabotropic glutamate receptors (mGluRs) have many important roles in regulation of
neuronal excitability and synaptic transmission. In hippocampal area CA1, activation of …

Depression and anxiety represent a major problem. However, the current treatment of both
groups of diseases is not satisfactory. As the glutamatergic system may play an important …

Metabotropic glutamate (mGlu) receptors respond to glutamate, the major excitatory
neurotransmitter in the mammalian brain, mediating a modulatory role that is critical for …

The application of the glutamate analogl-2-amino-4-phosphonobutyric acid (l-AP4) to
neurons produces a suppression of synaptic transmission. Althoughl-AP4 is a selective …