N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology

JR Moffett, B Ross, P Arun, CN Madhavarao… - Progress in …, 2007 - Elsevier
The brain is unique among organs in many respects, including its mechanisms of lipid
synthesis and energy production. The nervous system-specific metabolite N-acetylaspartate …

Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options

A Andravizou, E Dardiotis, A Artemiadis… - Autoimmunity …, 2019 - Springer
Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system
characterized by focal or diffuse inflammation, demyelination, axonal loss and …

Imaging outcomes for neuroprotection and repair in multiple sclerosis trials

F Barkhof, PA Calabresi, DH Miller… - Nature Reviews …, 2009 - nature.com
Multiple sclerosis (MS) is commonly regarded as an inflammatory disease, but it also has a
neurodegenerative component, which represents an additional target for treatment. The use …

Multiple sclerosis: the role of MR imaging

Y Ge - American Journal of Neuroradiology, 2006 - Am Soc Neuroradiology
MR offers by far the most sensitive technique for detecting multiple sclerosis (MS) lesions
and has proved to be an important paraclinical tool for diagnosing MS and monitoring …

Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations

Multiple Sclerosis Therapy Consensus Group … - Journal of …, 2008 - Springer
This review updates and extends earlier Consensus Reports related to current basic and
escalating immunomodulatory treatments in multiple sclerosis (MS). The recent literature …

Axonal damage in multiple sclerosis

JD Haines, M Inglese… - Mount Sinai Journal of …, 2011 - Wiley Online Library
Multiple sclerosis is a debilitating disease of the central nervous system that has been
characteristically classified as an immune‐mediated destruction of myelin, the protective …

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease

K Kantarci, SD Weigand, RC Petersen, BF Boeve… - Neurobiology of …, 2007 - Elsevier
Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of
disease progression in patients with amnestic mild cognitive impairment (MCI) and …

The mechanism of action of glatiramer acetate in multiple sclerosis and beyond

R Aharoni - Autoimmunity reviews, 2013 - Elsevier
In multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis
(EAE), the immune system reacts again self myelin constitutes in the central nervous system …

Mitochondria and disease progression in multiple sclerosis

D Mahad, H Lassmann… - … and applied neurobiology, 2008 - Wiley Online Library
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Recent evidence suggests that dysfunction of surviving demyelinated axons and …

Axonal degeneration in multiple sclerosis: the mitochondrial hypothesis

KG Su, G Banker, D Bourdette, M Forte - Current neurology and …, 2009 - Springer
Multiple sclerosis (MS) is a chronic disease of the central nervous system, affecting more
than 2 million people worldwide. Traditionally considered an inflammatory demyelinating …