Animal models of major depression: drawbacks and challenges
Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …
Is there a “metabolic-mood syndrome”? A review of the relationship between obesity and mood disorders
RB Mansur, E Brietzke, RS McIntyre - Neuroscience & Biobehavioral …, 2015 - Elsevier
Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies
have highlighted the public health relevance of this association, insofar as both conditions …
have highlighted the public health relevance of this association, insofar as both conditions …
Hippocampal function is impaired by a short-term high-fat diet in mice: Increased blood–brain barrier permeability and neuroinflammation as triggering events
Worldwide, and especially in Western civilizations, most of the staple diets contain high
amounts of fat and refined carbohydrates, leading to an increasing number of obese …
amounts of fat and refined carbohydrates, leading to an increasing number of obese …
Central and peripheral inflammation link metabolic syndrome and major depressive disorder
Metabolic syndrome and major depression are two of the most common and debilitating
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
disorders worldwide, occurring with significant rates of comorbidity. Recent studies have …
Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour
JK Knudsen, TY Michaelsen, C Bundgaard-Nielsen… - Scientific reports, 2021 - nature.com
Differences in gut microbiota composition have been observed in patients with major
depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal …
depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal …
Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
Epidemiological studies indicate that insulin resistance (IR), a hallmark of type 2 diabetes, is
associated with an increased risk of major depression. Here, we demonstrated that male …
associated with an increased risk of major depression. Here, we demonstrated that male …
High‐fat diet‐induced metabolic disorders impairs 5‐HT function and anxiety‐like behavior in mice
J Zemdegs, G Quesseveur, D Jarriault… - British journal of …, 2016 - Wiley Online Library
Background and Purpose The link between type 2 diabetes mellitus (T2DM) and depression
is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic …
is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic …
The flinders sensitive line rat model of depression—25 years and still producing
DH Overstreet, G Wegener - Pharmacological reviews, 2013 - ASPET
Approximately 25 years have passed since the first publication suggesting the Flinders
sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on …
sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on …
Is increased antidepressant exposure a contributory factor to the obesity pandemic?
Major depressive disorder (MDD) and obesity are both common heterogeneous disorders
with complex aetiology, with a major impact on public health. Antidepressant prescribing has …
with complex aetiology, with a major impact on public health. Antidepressant prescribing has …
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
Comorbidity exists between metabolic disorders and depressive syndrome with unclear
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …