Background Dietary nitrate has a controversial role in human health. For over half a century,
the nitrate content of the three major dietary sources–vegetables, meat, and water–has been …

Cannabis can synthetize more than 400 compounds, including terpenes, flavonoids, and
more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9 …

Single-stranded oligonucleotides have been explored as a therapeutic modality for more
than 20 years. Only during the last 5 years have single-stranded oligonucleotides become a …

Oligonucleotide-based therapies are a promising approach for treating a wide range of hard-
to-treat diseases, particularly genetic and rare diseases. These therapies involve the use of …

Background Endogenous gasotransmitters are small gaseous mediators that can be
generated endogenously by mammalian organisms. The dysregulation of the …

Iron, the most abundant transition metal ion in humans, participates in the biosynthesis,
translocation, signal transduction, and transformation of nitric oxide through its …

Tafenoquine is a highly effective treatment for Babesia microti infections in animal models.
An immunocompromised patient infected by a strain of B. microti that was at least partially …

Netarsudil ophthalmic solution is a novel topical intraocular pressure (IOP)-lowering agent
that has recently been approved by the US Food and Drug Administration (FDA) for the …

Healthcare systems worldwide are struggling to find ways to fund the cost of innovative
treatments such as gene therapies, regenerative medicine, and monoclonal antibodies …

Nitric oxide (NO) signaling has been studied in the eye, including in the pathophysiology of
some eye diseases. While NO production by nitric oxide synthase (NOS) enzymes in the eye …