The multidrug resistance phenomenon presents a major threat to the pharmaceutical
industry. This resistance is a common occurrence in several diseases and is mediated by …

In recent years, there has been an increased understanding of P-glycoprotein (P-GP)-
mediated pharmacokinetic interactions. In addition, its role in modifying the bioavailability of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). There is a dire need for novel effective antivirals to …

Purpose. To investigate whether d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)
functions as an inhibitor of P-glycoprotein (P-gp), the multidrug resistance transporter …

Interindividual differences of drug response are an important cause of treatment failures and
adverse drug reactions. The identification of polymorphisms explaining distinct phenotypes …

Background. Lethal midline granuloma is now considered to be a malignant lymphoma
derived from peripheral T cells or from natural killer cells. The therapeutic outcome of nasal …

The clinical management of tacrolimus, a macrolide used as immunosuppressant after
transplantation, is complicated by its narrow therapeutic index in combination with inter-and …

SIMULTANEOUS RESISTANCE of tumour cells to multiple cytotoxic drugs (multidrug
resistance, MDR) is a major limitation to the successful chemotherapeutic treatment of …

Abstract P-glycoprotein (ABCB1, MDR1) belongs to the ABC transporter family transporting
a wide range of drugs and xenobiotics from intra-to extracellular at many biological …

Resistance to chemotherapy is a critical issue in the management of breast cancer patients.
The nature of clinical drug resistance is likely to be multifactorial. However, in the last …