Lineage plasticity, a process whereby cells change their phenotype to take on a different
molecular and/or histologic identity, is a key driver of cancer progression and therapy …

Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …

Cancer stem cells (CSCs) also known as cancer-initiating cells (CIC), are responsible for the
sustained and uncontrolled growth of malignant tumors and are proposed to play significant …

Despite the tremendous advances in cancer treatment, resistance to chemotherapeutic
agents impedes higher success rates and accounts for major relapses in cancer therapy …

Background: Breast cancer stem cells (BCSCs) play an essential role in facilitating breast
cancer relapse and metastasis. The underlying mechanism, however, remains incompletely …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of abundant
desmoplastic stroma primarily composed of cancer-associated fibroblasts (CAFs). It is …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a disease of unmet medical need.
While immunotherapy with chimeric antigen receptor T (CAR-T) cells has shown much …

Both genetic and epigenetic mechanisms intimately regulate cancer development and
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …

Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is
the 4th most frequent cause of cancer-related death worldwide, primarily due to the inherent …

Pancreatic cancer stem cells (PaCSCs) drive pancreatic cancer tumorigenesis,
chemoresistance and metastasis. While eliminating this subpopulation of cells would …