Lipid metabolism in T cell signaling and function
T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …
Current advance of nanotechnology in diagnosis and treatment for malignant tumors
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …
field that is garnering a lot of interest and investigation. Nanomedicine shows great potential …
Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol
The interplay between western diet and gut microbiota drives the development of non-
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. However …
Antioxidant therapy in cancer: rationale and progress
Cancer is characterized by increased oxidative stress, an imbalance between reactive
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …
oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of …
Ginseng-derived nanoparticles alter macrophage polarization to inhibit melanoma growth
M Cao, H Yan, X Han, L Weng, Q Wei, X Sun… - … for immunotherapy of …, 2019 - Springer
Background It is unclear whether plant-derived extracellular vesicles (EVs) can mediate
interspecies communication with mammalian cells. Tumor-associated macrophages (TAMs) …
interspecies communication with mammalian cells. Tumor-associated macrophages (TAMs) …
Tumor-associated macrophages in hepatocellular carcinoma pathogenesis, prognosis and therapy
Simple Summary Hepatocellular carcinoma (HCC) constitutes a major health burden,
accounting for> 80% of primary liver cancers globally. Inflammation has come into the …
accounting for> 80% of primary liver cancers globally. Inflammation has come into the …
Prognostic signatures of sphingolipids: Understanding the immune landscape and predictive role in immunotherapy response and outcomes of hepatocellular …
X Zhang, J Zhuge, J Liu, Z Xia, H Wang, Q Gao… - Frontiers in …, 2023 - frontiersin.org
Background Hepatocellular carcinoma (HCC) is a complex disease with a poor outlook for
patients in advanced stages. Immune cells play an important role in the progression of HCC …
patients in advanced stages. Immune cells play an important role in the progression of HCC …
Targeting tumor-associated macrophages as an antitumor strategy
N Cheng, X Bai, Y Shu, O Ahmad, P Shen - Biochemical pharmacology, 2021 - Elsevier
Tumor-associated macrophages (TAMs) are the most widely infiltrating immune cells in the
tumor microenvironment (TME). Clinically, the number of TAMs is closely correlated with …
tumor microenvironment (TME). Clinically, the number of TAMs is closely correlated with …
Targeted and immune-based therapies for hepatocellular carcinoma
Treatment options for patients with hepatocellular carcinoma are rapidly changing based on
positive results from phase 3 trials of targeted and immune-based therapies. More agents …
positive results from phase 3 trials of targeted and immune-based therapies. More agents …
Targeting M2-like tumor-associated macrophages is a potential therapeutic approach to overcome antitumor drug resistance
S Wang, J Wang, Z Chen, J Luo, W Guo, L Sun… - NPJ Precision …, 2024 - nature.com
Tumor drug resistance emerges from the interaction of two critical factors: tumor cellular
heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME) …
heterogeneity and the immunosuppressive nature of the tumor microenvironment (TME) …