Our body keeps separating the toxic chemicals in the blood from the brain. A significant
number of drugs do not enter the central nervous system (CNS) due to the blood-brain …

Brain iron homeostasis is maintained through the normal function of blood–brain barrier and
iron regulation at the systemic and cellular levels, which is fundamental to normal brain …

The arachnoid barrier, a component of the blood-cerebrospinal fluid barrier (B-CSFB) in the
meninges, is composed of epithelial-like, tight-junction-expressing cells. Unlike other central …

Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …

Chemotherapy has an essential role not only in advanced solid tumor therapy intervention
but also in society's health at large. Chemoresistance, however, seriously restricts the …

Abstract Blood‐brain‐barrier (BBB) disruption has been associated with a variety of central‐
nervous‐system diseases. In vitro BBB models enable to investigate how the barrier reacts …

Cerebral ischemic stroke remains one of the most serious neurological disorders that pose
threats to human health, causing a large amount of long-term disability or even death …

Background Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory
processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB …

Background Major depressive disorder (MDD) is the leading cause of disability worldwide.
Of individuals with MDD, 30% to 50% are unresponsive to common antidepressants …

Carbon quantum dots (CQDs) have received increasing attention in recent years for their
potential toxicity. However, little is known about their neurobehavioral toxicity. This study …