Abstract Purpose of Review Low-grade gliomas (LGG) are a group of primary brain tumors
that arise from supporting glial cells. They are characterized by a mutation in the isocitrate …

Reprogramming of energy metabolism is one of the basic characteristics of cancer and has
been proved to be an important cancer treatment strategy. Isocitrate dehydrogenases (IDHs) …

Gliomas represent the most common primary brain tumor in adults. Low-grade gliomas
(LGGs) are indolent tumors that almost universally progress to high-grade secondary …

NAD+ use is an ancestral trait of isocitrate dehydrogenase (IDH) and the NADP+ phenotype
arose through evolution as an ancient adaptation event. However, no NAD+-specific IDHs …

Tributyltin (TBT) is known to cause developmental defects as endocrine disruptive chemicals
(EDCs). At nanomoler concentrations, TBT actions were mediated by genomic pathways via …

We have determined the catalytic mechanism of the human cytosolic homodimeric isocitrate
dehydrogenase (hICDH), an enzyme involved in the regulation of tumorogenesis. Our study …

Isocitrate dehydrogenase is an enzyme converting isocitrate to α-ketoglutarate in the
canonical tricarboxylic acid (TCA) cycle. There are three different types of isocitrate …

Pseudomonas aeruginosa is the leading pathogen of chronic cystic fibrosis (CF) lung
infection. Life-long persistence in the inflamed and ever fluctuating CF lungs results in the …

Isocitrate dehydrogenases (IDHs) are metabolic enzymes that catalyze the oxidative
decarboxylation of isocitrate to α-ketoglutarate. Depending on the electron acceptor and …

Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion
of isocitrate to α-ketoglutarate (αKG) to provide critical cytosolic substrates and drive NADPH …