Hypercalcemia and hyperphosphatemia associate with an elevated risk of cardiovascular
events, yet the pathophysiological basis of this association is unclear. Disturbed mineral …

Here, we discuss pathophysiological approaches to the defining of endothelial dysfunction
criteria (ie, endothelial activation, impaired endothelial mechanotransduction, endothelial-to …

Plasma approaches metastability with respect to its calcium and phosphate content, with
only minor perturbations in ionic activity needed to sustain crystal growth once nucleated …

Protein-mineral interaction is known to regulate biomineral stability and morphology. We
hypothesise that fluid phases produce highly dynamic protein-mineral complexes involved …

Calciprotein particles (CPPs) represent an inherent mineral buffering system responsible for
the scavenging of excessive Ca2+ and PO43− ions in order to prevent extraskeletal …

Albeit multiple studies demonstrated that vasa vasorum (VV) have a crucial importance in
vascular pathology, the informative markers and metrics of vascular inflammation defining …

Calciprotein particles (CPPs), which increasingly arise in the circulation during the disorders
of mineral homeostasis, represent a double-edged sword protecting the human organism …

Cardiovascular complications are one of the leading causes of mortality worldwide and are
strongly associated with atherosclerosis and vascular calcification (VC). Patients with …

ABSTRACT Background Calciprotein particles (CPPs), colloidal mineral-protein
nanoparticles, have emerged as potential mediators of phosphate toxicity in dialysis …

Magnesium (Mg) plays crucial roles in multiple essential biological processes. As the
kidneys are the primary organ responsible for maintaining the blood concentration of Mg …