This review discusses a set of instrumental and computational methods that are used to
characterize hydrated forms of APIs (active pharmaceutical ingredients). The focus has been …

This commentary critically evaluated the unique effects of water vapor sorption by
multicomponent solid forms of active pharmaceutical ingredients (APIs), and its effects on …

Allopurinol (ALO) is a medication that treats gout and kidney stones by lowering uric acid
synthesis in the blood. The biopharmaceutics classification system (BCS) IV drug exhibits …

The propensity of molecular organic compounds to form stoichiometric or nonstoichiometric
crystalline hydrates remains a challenging aspect of crystal engineering and is of practical …

A search for new solid forms of an active pharmaceutical ingredient (API) is an integral part
of the drug product development process. The studied compound, Ibrutinib, is a recently …

Background: Crystal engineering is dealing with the creation of new structures and new
properties in drug molecules through inter-molecular interactions. Researchers of …

Predictions of the structures of stoichiometric, fractional, or nonstoichiometric hydrates of
organic molecular crystals are immensely challenging due to the extensive search space of …

This research dealt with the multicomponent crystal developed from diclofenac potassium
and l-proline to improve the pharmaceutical performance of this anti-inflammatory drug …

Sitagliptin is an antihyperglycemic drug used in adults for the treatment of diabetes Type 2.
Literature data and in-house experiments were applied in this monograph to assess whether …

The aim of this study was to improve rivaroxaban water-solubility by cocrystal preparation
and to understand this process. The screening with water-soluble coformers was performed …