Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …

Huntington's disease is a progressive neurological disorder that starts insidiously with motor,
cognitive or psychiatric disturbance, and progresses through a distressing range of …

Objective Narcolepsy type 1 (NT1) is assumed to be caused solely by a lack of hypocretin
(orexin) neurotransmission. Recently, however, we found an 88% reduction in corticotropin …

Histamine and hypocretin neurons are localized to the hypothalamus, a brain area critical to
autonomic function and sleep. Narcolepsy type 1, also known as narcolepsy with cataplexy …

Alzheimer's disease is a neurodegenerative disorder characterized by extracellular amyloid
plaque deposits, mainly composed of amyloid-beta peptide and intracellular neurofibrillary …

Histaminergic neurons are exclusively located in the hypothalamic tuberomamillary nucleus,
from where they project to many brain areas. The histaminergic system is involved in basic …

Circadian clocks allow anticipation of daily environmental changes [1]. The suprachiasmatic
nucleus (SCN) houses the master clock, but clocks are also widely expressed elsewhere in …

All mammalian cells exhibit circadian rhythm in cellular metabolism and energetics.
Autonomous cellular clocks are modulated by various pathways that are essential for robust …

Histamine, which is synthesized by histidine decarboxylase (HDC), does not only modulate
the immune system, but is also acting as a neurotransmitter. Histaminergic neurons project …