Sex-specific DNA methylation: impact on human health and development

P Govender, M Ghai, M Okpeku - Molecular Genetics and Genomics, 2022 - Springer
Human evolution has shaped gender differences between males and females. Over the
years, scientific studies have proposed that epigenetic modifications significantly influence …

Neurotoxic effects of heavy metal pollutants in the environment: Focusing on epigenetic mechanisms

G Yu, L Wu, Q Su, X Ji, J Zhou, S Wu, Y Tang… - Environmental Pollution, 2024 - Elsevier
The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Metals exposures and DNA methylation: current evidence and future directions

ER Elkin, C Higgins, MT Aung, KM Bakulski - Current environmental health …, 2022 - Springer
Abstract Purpose of the Review Exposure to essential and non-essential metals is
widespread. Metals exposure is linked to epigenetic, particularly DNA methylation …

[HTML][HTML] Translational toxicoepigenetic meta-analyses identify homologous gene DNA methylation reprogramming following developmental phthalate and lead …

RL Petroff, DC Dolinoy, K Wang, L Montrose… - Environment …, 2024 - Elsevier
Although toxicology uses animal models to represent real-world human health scenarios, a
critical translational gap between laboratory-based studies and epidemiology remains. In …

Epigenetic alteration shaped by the environmental chemical bisphenol A

T Qin, X Zhang, T Guo, T Yang, Y Gao, W Hao… - Frontiers in …, 2021 - frontiersin.org
Bisphenol A (BPA) is extensively used in plastic products and epoxy resins. The epigenetic
response to the environmental chemical BPA was involved in multiple dysfunctional …

Sex-based disparities in DNA methylation and gene expression in late-gestation mouse placentas

LM Legault, M Breton-Larrivée… - Biology of sex …, 2024 - Springer
Background The placenta is vital for fetal development and its contributions to various
developmental issues, such as pregnancy complications, fetal growth restriction, and …

Toxicoepigenetics and environmental health: Challenges and opportunities

LK Svoboda, BPU Perera, RK Morgan… - Chemical research in …, 2022 - ACS Publications
The rapidly growing field of toxicoepigenetics seeks to understand how toxicant exposures
interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field …

Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice

RL Petroff, RG Cavalcante, JA Colacino… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: The developing epigenome changes rapidly, potentially making it more
sensitive to toxicant exposures. DNA modifications, including methylation and …

Maternal exposure to atmospheric PM2. 5 and fetal brain development: Associations with BAI1 methylation and thyroid hormones

Z Zeng, X Xu, Q Wang, Z Zhang, P Meng, X Huo - Environmental Pollution, 2022 - Elsevier
Highlights•The e-waste exposed pregnant women have a greater chronic daily intake of PM
2.5.•Maternal PM 2.5 exposure is associated with neonatal BAI1 methylation at 2 …

Best practices for epigenome-wide DNA modification data collection and analysis

J Kochmanski, AI Bernstein - Rigor and Reproducibility in Genetics and …, 2024 - Elsevier
In response to a series of analyses that revealed very low reproducibility of studies in life
sciences, many initiatives have been launched to assist, establish, and improve standards …